Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model

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Involvement of high mobility group box-1 in imiquimod-induced psoriasis-like mice model.

In the previous work, we have indicated that HMGB1, a pro-inflammatory cytokine, is closely associated with the pathogenesis of psoriasis. To further clarify the role of HMGB1 in the pathogenesis of psoriasis, we investigated the direct function of HMGB1 application and HMGB1 blockade in imiquimod (IMQ)-induced psoriatic mouse model in this study. Mice were treated with imiquimod (IMQ) to induc...

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ژورنال

عنوان ژورنال: The Journal of Dermatology

سال: 2016

ISSN: 0385-2407

DOI: 10.1111/1346-8138.13695